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Real members of mySMAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
July 21, 2025
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Several types of muscle relaxants can help manage muscle stiffness and tightness in SMA:

• Baclofen (available as Gablofen and Lioresal)
• Tizanidine (found in Comfort Pac-tizanidine and Zanaflex)
• Benzodiazepines

These medications work by reducing signal strength between nerve and muscle cells, which helps decrease Show Full Answer

Several types of muscle relaxants can help manage muscle stiffness and tightness in SMA:

• Baclofen (available as Gablofen and Lioresal)
• Tizanidine (found in Comfort Pac-tizanidine and Zanaflex)
• Benzodiazepines

These medications work by reducing signal strength between nerve and muscle cells, which helps decrease muscle tension, spasms and associated pain. Beyond oral medications, other medical treatments include:

• Local injections with Botox or phenol to reduce muscle tone
• Physical therapy combined with medication often works best
• Stretching exercises when possible
• Support devices like braces and splints

Always work with your healthcare team to determine the best treatment approach, as needs vary person to person.

July 21, 2025

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